Polynucleotides

What Are Polynucleotides?

Polynucleotides (PN) are natural molecules made up of long chains of nucleotides—the basic units of DNA and RNA. In aesthetics, they’re valued for their regenerative and anti-ageing effects. Most PN used in skincare are derived from salmon DNA or similar sources and are known for promoting tissue repair and cell renewal.

They help improve skin texture, elasticity, and hydration by stimulating fibroblasts and supporting skin regeneration. Though relatively new to the aesthetic market, PN treatments have gained popularity quickly, especially after going viral on social media for their subtle yet noticeable skin-rejuvenating results.

How Polynucleotides Are Delivered

In aesthetics, polynucleotides are typically delivered via microinjections into the dermis, targeting areas where cellular repair is most needed. This method helps boost skin regeneration, hydration, and elasticity, making it ideal for the face, neck, and décolletage.

The treatment is generally well tolerated and suitable for many skin types, including sensitive skin. However, since most polynucleotide products are derived from fish DNA (often salmon), they may not be appropriate for vegetarians or those with specific dietary restrictions or allergies.